Endocrine Abstracts

Background: Hyperandrogenism is infrequent in menopause, being the most common cause benign pathologies. However, it can also be produced by an ovarian or adrenal tumour. Correct diagnosis and location can be challenging because small lesions may not be visible with modern imaging studies. We report a case of ovarian stromal hyperplasia where selective venous catheterization and hormonal sampling were performed to find the origin of excessive androgen production.<p class="...

Congenital hypothyroidism (CH) is frequently associated with congenital heart defects (CHD). Thyroid defects may have a higher prevalence in children with CHD as embryonic thyroid gland share nuclear transcription factors with heart and great vessels during organogenesis. We investigated thyroid function in 325 children (165 M/160 F, aged 0.2–15.4 years), affected by CHD. Patients with Down syndrome, recent administration of iodinated contrast agents, low T3 sy...

Background: Although the majority of cases of hyperandrogenism in postmenopausal women are due to functional causes, the sudden appearance of a severe and rapidly progressive condition, especially if associated with signs of virilization and defeminization, requires always ruling out the existence of an androgen-producing tumor at both the adrenal and ovarian levels. Etiological diagnosis can be difficult because ovarian tumors are not easily demonstrable by imaging.<p cla...